Cell Biology
Jinhua Dong
Specially Appointed Professor
genetic EngineeringProtein EngineeringAntibody EngineeringImmunoassay
Research Projects
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Development and application of novel antibodies based on display technologies
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Studies on Open Sandwich Immunoassay and Quenchbody technology
| 2007-2009 | The University of Tokyo, Research Fellow |
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| 2009-2011 | JSPS Fellowship (The University of Tokyo) |
| 2011-2013 | Shizuoka University, Researcher, Assistant Prof. |
| 2013-2016 | Tokyo Institute of Technology, Assistant Prof. |
| 2016-2017 | Linyi University, School of Chemistry, Professor |
| 2017- | Tokyo Institute of Technology, Specially Appointed Professor |
| 2007 | Chinese Government Award for Outstanding Students Abroad |
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| 2015 | Fuji Sankei Business i, The 29th Originality innovation, High-Technology Award |
| 2017 | Excellent Paper Award of The Society for Biotechnology, Japan
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| 2020 | Dong, J., Miyake, C., Yasuda, T., Oyama, H., Morita, I., Tsukahara, T., Takahashi, M., Jeong, H.J., Kitaguchi, T., Kobayashi, N., and Ueda, H., PM Q-probe: a fluorescent binding protein that converts many antibodies to a fluorescent biosensor, Biosens. Bioelectron, 165,112425, 2020 Dong, J., Oka, Y., Jeong, H.J., Ohmuro-Matsuyama, Y., and Ueda, H., Detection and destruction of HER2-positive cancer cells by Ultra Quenchbody-siRNA complex, Biotechnol. Bioeng., 117, 1259-1269, 2020 |
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| 2019 | Cong, Y., Dong, H., Wei, X., Zhang, L., Bai, J., Wu, J., Huang, X.J., Gao, Z., Ueda, H. and Dong, J., A novel murine antibody and an Open sandwich immunoassay for the detection of clenbuterol, Ecotoxicol. Environ. Saf., 182,109473, 2019 Gong, Z., Liu, X., Dong, J., Zhang, W., Jiang, Y., Zhang, J., Feng, W., Chen, K., Bai, J., Transition from vesicles to nanofibres in the enzymatic self-assemblies of an amphiphilic peptide as an antitumour drug carrier, Nanoscale, 11(33):15479-15486, 2019 |
| 2018 | Dong, J., Fujita, R., Zako, T., Ueda, H., Construction of Quenchbodies to detect and image Amyloid β oligomers, Anal. Biochem., 550,61-67, 2018 Zhao, S., Dong, J., Jeong, H.J., Okumura, K., Ueda, H., Rapid detection of the neonicotinoid insecticide imidacloprid using a quenchbody assay, Anal. Bioanal. Chem., 410(17),4219-4226, 2018 Su, J., Dong, J., Kitaguchi, T., Ohmuro-Matsuyama, Y., Ueda, H., Noncompetitive homogeneous immunodetection of small molecules based on β-glucuronidase complementation, Analyst, 143, 2096-2101, 2018 |
| 2017 | Dong, J., Shichiri, M., Chung, C.I., Shibata, T., Uchida, K., Hagihara, Y., Yoshida, Y., Ueda, H., An Open Sandwich immunoassay for detection of 13(R,S)-Hydroxy-9(E),11(E)-octadecadienoic acid, Analyst, 142(5), 787-793, 2017 Dong, J., Ueda, H., ELISA-type assays of trace biomarkers using microfluidic methods, WIREs Nanomed. Nanobiotechnol., e1457, 2017 Wongso, D., Dong, J., Ueda, H., Kitaguchi, T., Flashbody: a next generation Fluobody with fluorescence intensity enhanced by antigen binding, Anal. Chem., 89(12),6719-6725, 2017 Jeong, H.J., Kawamura, T., Iida, M., Kawahigashi, Y., Takigawa, M., Ohmuro-Matsuyama, M., Chung, C.I., Dong, J., Kondoh, M., Ueda, H., Development of a Quenchbody for the detection and imaging of the cancer-related tight-junction-associated membrane protein claudin, Anal Chem., 89(20),10783-10789, 2017 |
| 2016 | Dong, J., Jeong, H.J., Ueda, H., Preparation of Quenchbodies by protein transamination reaction, J. Biosci. Bioeng., 122(1), 125-130, 2016 |
| 2015 | Dong, J., Kojima, T., Ohashi H., Ueda, H., Optimal fusion of antibody binding domains resulted in higher affinity and wider specificity, J. Biosci. Bioeng., 120(5),504-9, 2015 Chung, C.I., Makino, R., Dong, J., Ueda, H., Open flower fluoroimmunoassay: a general method to make fluorescent protein-based immunosensor probes, Anal. Chem., 87(6), 3513-9, 2015 |
| 2014 | Dong, J., Otsuki, T., Kato, T., Park, E.Y., Tracking Neospora caninum parasites using chimera monoclonal antibodies against its surface antigen-related sequences (rNcSRS2), J. Biosci. Bioeng., 117(3), 351-357, 2014 |
| 2013 | Zhou, H.*, Dong, J.*, Deo, V.K., Park, E.Y., Lee, J. Detection of anti-Neospora antibodies in bovine serum by using spiky Au-CdTe nanocomplexes, Sens. actuators. B Chem., 178,192-199 (2013) *equal contributions Dong, J., Sakurai, A., Nomura, N., Park, E.Y., Shibasaki, F., Ueda, H., Isolation of recombinant phage antibodies targeting the hemagglutinin cleavage site of highly pathogenic avian influenza virus, PloS One, 8(4), e61158, 2013 |
| 2012 | Dong, J., Otsuki, T., Kato, T., Park, E.Y., Development of a diagnostic method for neosporosis in cattle using recombinant Neospora caninum proteins, BMC Biotechnol., 12,19, 2012 |
| 2011 | Islam, K., Ihara, M., Dong, J., Kasagi, N., Mori, T., Ueda, H., Direct construction of open-sandwich enzyme immunoassay for one-step noncompetitive detection of thyroid hormone T4, Anal. Chem., 83(3),1008-1014, 2011 |
| 2009 | Dong, J., Ihara, M., Ueda, H., Antibody Fab display system that can perform open-sandwich ELISA, Anal. Biochem., 386(1),36-44, 2009 |
| 2007 | Dong, J., Tamaru, Araki, T., Molecular cloning, expression, and characterization of a β-agarase gene, agaD, from a marine bacterium, Vibrio sp. strain PO-303, Biosci. Biotechnol. Biochem., 71(1),38-46, 2007 Dong, J., Tamaru, Y., Araki, T., A unique β-agarase, AgaA, from a marine bacterium, Vibrio sp. strain PO-303, Appl. Microbiol. Biot., 74(6),1248-1255, 2007 |
| 2006 | Dong, J., Hashikawa, S., Konishi, T., Tamaru, Y., Araki, T., Cloning of the novel gene encoding β-Agarase C from a marine bacterium, Vibrio sp. strain PO-303, and characterization of the gene product, Appl. Environ. Microbiol., 72(9),6399-6410, 2006 |