Cell Biology
Hiroshi Kimura
Professor
EpigeneticsGene RegulationLive cell imagingNuclear Function
Topics
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Dr. Kimura was awarded by the Ministry of Education, Culture, Sports, Science and Technology, Japan.
Awards for Science and Technology (Research Category) -
Visualized histone H4K20 monomethylation dynamics in living cells, published in Journal of Molecular Biology
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Received the 2015 Robert Feulgen Prize
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Revealed the role of histone acetylation in gene activation by live cell imaging, published in Nature
1996-2002 | Postdoctoral Fellow, Univ. Oxford |
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2002-2003 | Associate Professor, MRI, Tokyo Med. Dent. Univ. |
2003-2007 | Principal Investigator, HMRO, Grad. Sch. Med., Kyoto Univ |
2007-2014 | Associate Professor, Grad. Sch. Frontier Biosci., Osaka Univ. |
2014-2016 | Professor, Grad. Sch. Biosci. Biotech., Tokyo Tech. |
2016- | Professor, Inst. Innov. Res., Tokyo Tech. |
2009 | Best paper award, Japan Society of Cell Biology |
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2015 | Robert Feulgen Prize, The Society for Histochemistry |
2021 | Awards for Science and Technology (Research Category), The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology |
2020 | Ioana Olan, Aled J. Parry, Stefan Schoenfelder, Masako Narita, Yoko Ito, Adelyne S. L. Chan, Guy St.C. Slater, Dóra Bihary, Masashige Bando, Katsuhiko Shirahige, Hiroshi Kimura, Shamith A. Samarajiwa, Peter Fraser & Masashi Narita. Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence. Nat Commun. 11, Article number: 6049 (2020) |
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2020 | Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Shoko Sato, Masaru Nakao, Naoki Goto, Hitoshi Kurumizaka, Yasuyuki Ohkawa & Hiroshi Kimura. Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input. Nature Protocols volume 15, pages3334–3360(2020) |
2020 | , , , , , , , |
2019 | Ryuichiro Nakato, Youichiro Wada, Ryo Nakaki, Genta Nagae, Yuki Katou, Shuichi Tsutsumi, Natsu Nakajima, Hiroshi Fukuhara, Atsushi Iguchi, Takahide Kohro, Yasuharu Kanki, Yutaka Saito, Mika Kobayashi, Akashi Izumi-Taguchi, Naoki Osato, Kenji Tatsuno, Asuka Kamio, Yoko Hayashi-Takanaka, Hiromi Wada, Shinzo Ohta, Masanori Aikawa, Hiroyuki Nakajima, Masaki Nakamura, Rebecca C McGee, Kyle W Heppner, Tatsuo Kawakatsu, Michiru Genno, Hiroshi Yanase, Haruki Kume, Takaaki Senbonmatsu, Yukio Homma, Shigeyuki Nishimura, Toutai Mitsuyama, Hiroyuki Aburatani, Hiroshi Kimura, Katsuhiko Shirahige. Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells. Epigenetics & Chromatin volume 12, Article number: 77 (2019) |
2019 | Yuko Sato, Lennart Hilbert, Haruka Oda, Yinan Wan, John M Heddleston, Teng-Leong Chew, Vasily Zaburdaev, Philipp Keller, Timothee Lionnet, Nadine Vastenhouw, Hiroshi Kimura. Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis. |
2019 | Akihito Harada, Kazumitsu Maehara, Tetsuya Handa, Yasuhiro Arimura, Jumpei Nogami, Yoko Hayashi-Takanaka, Katsuhiko Shirahige, Hitoshi Kurumizaka, Hiroshi Kimura & Yasuyuki Ohkawa. A chromatin integration labelling method enables epigenomic profiling with lower input. Nature Cell Biology volume 21, pages287–296(2019) |
2019 | Ning Zhao, Kouta Kamijo, Philip D. Fox, Haruka Oda, Tatsuya Morisaki, Yuko Sato, Hiroshi Kimura & Timothy J. Stasevich. A genetically encoded probe for imaging nascent and mature HA-tagged proteins in vivo. Nat Commun. 10, Article number: 2947 (2019) |
2018 | Parry AJ, Hoare M, Bihary D, Hänsel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D’Santos P, Russell IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M. NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nat Commun. 2018 May 9;9(1):1840. |
2017 | Imre L, Simándi Z, Horváth A, Fenyőfalvi G, Nánási P, Niaki EF, Hegedüs É, Bacsó Z, Weyemi U, Mauser R, Ausio J, Jeltsch A, Bonner W, Nagy L, Kimura H, Szabó G. Partolina M, Thoms HC, MacLeod KG, Rodriguez-Blanco G, Clarke MN, Venkatasubramani AV, Beesoo R, Larionov V, Neergheen-Bhujun VS, Serrels B, Kimura H, Carragher NO, Kagansky A. Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array. Cell Death Discov 2017, 3:16077. |
2016 | Sato Y, Kujirai T, Arai R, Asakawa H, Ohtsuki C, Horikoshi N, Yamagata K, Ueda J, Nagase T, Haraguchi T, Hiraoka Y, Kimura A, Kurumizaka H, Kimura H. A genetically encoded probe for live-cell imaging of H4K20 monomethylation. J Mol Biol 428, 3885-3902, 2016. |
2015 | Hayashi-Takanaka Y, Maehara K, Harada A, Umehara T, Yokoyama S, Obuse C, Ohkawa Y, Nozaki N, Kimura H. Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies, Chromosome Res 23, 753-766, 2015. Dias JD, Rito T, Torlai Triglia E, Kukalev A, Ferrai C, Chotalia M, Brookes E, Kimura H, Pombo A. Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells, eLife 4, e11215, 2015. |
2014 | Strasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H. Regulation of RNA polymerace Ⅱ activation by histone acetylation in single living cells. Nature 516, 272-275, 2014. |