Cell Biology
Hideki Taguchi
Professor
BiochemistryProtein sciencechaperoneprionnascent-chain biology
Research Projects
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Molecular mechanism of molecular chaperones in the cell
Topics
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New insights into Protein Synthesis
| 1995-2003 | Research Associate, CRL, Tokyo Tech. |
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| 2003-2010 | Assoc. Prof., Grad. Sch. of Frontier Science, Univ. of Tokyo |
| 2010-2016 | Professor, Graduate School of Bioscience and Biotechnology, Tokyo Tech. |
| 2016- | Professor, IIR, Tokyo Tech. |
| 2016 | Chadani Y, Niwa T, Chiba S, Taguchi, H.*, Ito K.* Integrated in vivo and in vitro nascent chain profiling reveals widespread translational pausing. Proc Natl Acad Sci USA. 113, E829-38 (2016) |
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| 2012 | Niwa, T., Kanamori T., *Ueda, T., *Taguchi, H. Global Analysis of Chaperone Effects Using a Reconstituted Cell-Free Translation System. Proc. Natl. Acad. Sci. U.S.A. 109, 8937-8942 (2012) |
| 2010 | Fujiwara, K., Ishihama, Y., Nakahigashi, K., Soga, T. and Taguchi, H.* A systematic survey of in vivo obligate chaperonin-dependent substrates. EMBO J. 29, 1552-1564 (2010) Kawai-Noma, S., Pack, C-G., Kojidani, T., Asakawa, H., Hiraoka, Y., Kinjo, M., Haraguchi, T., Taguchi, H.*, and Hirata, A. In vivo evidence for the fibrillar structures of Sup35 prions in yeast cells. J. Cell Biol. 190, 223-231 (2010) |
| 2009 | Niwa, T., Ying, B.-W., Saito, K., Jin, W. Z., Takada, S., Ueda, T. Taguchi, H.* Bimodal protein solubility distribution revealed by an aggregation analysis of the entire ensemble of Escherichia coli proteins. Proc. Natl. Acad. Sci. U.S.A. 106, 4201-4206 (2009) |
| 2004 | Ueno, T., Taguchi, H., Tadakuma, H., Yoshida, M.*, Funatsu, T.* GroEL mediates protein folding with a two successive timer mechanism. Mol. Cell 14, 423-434 (2004) |
| 2001 | Taguchi, H., Ueno, T., Tadakuma, H., Yoshida, M.*, Funatsu, T.* Single-molecule observation of protein-protein interactions in the chaperonin system. Nat. Biotechnol. 19, 861-865 (2001) |