Social Implementation
Yukako Yagi
Visiting Associate Professor
Pathology
Biography
Summary in 2018
In 2018, we made great progress in each of our research projects and expanded the breadth of our research through both internal and external collaborations. We have also increased in size, welcoming a fantastic Research Fellow, Sr. Data Analyst, Data Scientist and Machine Learning Engineer to the lab.
Over the course of 2017, our efforts were focused on building a foundation for a lab capable of advanced pathology digital imaging to pursue multi-disciplinary research projects with potential clinical applicability. Due to the hard work of my team and collaborators, 2018 proved to be a successful year of research for our lab. This year, we have established a protocol for each project with consideration of their connectivity. This allowed us to identify where and how to implement deep learning and AI in a way that is useful to treatment and diagnosis. The three major tasks of our lab are (1) basic technology development, (2) multimodality advanced imaging, and (3) advanced Whole Slide Imaging (WSI) such as confocal imaging and histology 3D imaging.
As WSI continues to grow in popularity, so does the need for a reliable mechanism for quality assurance and standardization. We are working to develop the next generation of slide/image quality evaluation and color standardization between scanners. We are also working to develop a standard protocol to evaluate the outcome of image and AI analysis, by partnering with an International organizations.
Micro-CT
Multimodality imaging uses several modalities such as CT, MRI, WSI and molecular test to analyze the variation of cell or organ due to disease by engineering technologies and clarify its relationship.
Micro-CT in medicine is a new modality and we strongly believe that it will play a very important role in the future of patient care. It is the pipeline which connects in-vivo imaging and ex-vivo imaging.
Since 2018, we have been exploring the possibilities of micro-CT in more than 10 specialties in pathology. Our studies have found that the benefits of using micro-CT are multifaceted, as it can be used (1) for margin detection by fresh tissue scanning-> frozen section diagnosis, (2) Whole block imaging to observe an entire block instead of several slides-> evaluate all materials from patient and (3) Multimodality imaging-> to improve diagnosis in each modality and use data for teaching purposes.
Our findings prove that micro-CT creates the possibility for a multimodality decision support system that can help us obtain a deeper understanding of cancer.
Advanced WSI Research
We continue to improve our automated FISH scoring project, expanding our project to Hodgkin lymphoma, which will begin in 2019. Additionally, our automated CISH scoring project will be applied to breast cancer cases, and has already shown a high possibility for clinical application in the near future.
Our project on histology 3D imaging for lung adenocarcinoma has been presented at international conferences and has impressed audience members whilst increasing interest in our research. Through histology 3D imaging and multiplex immuno fluorescence 3D imaging, we are demonstrating a previously unknown mechanism for cancer growth in a specific type of lung adenocarcinoma. This novel technology can be applied to any organ system’s cancer research.
Through our research projects listed above, we have received many requests from other departments for collaboration.
Research Projects
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Standardization of many aspects of pathology imaging, such as color and image quality calibration
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Evaluation and optimization of digital staining
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3D and multimodality pathological imaging
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Decision support systems for pathology diagnosis, research, and education
| 2007 - 2008 | Harvard Medical School, Pathology, Instructor |
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| 2008 - 2016 | Harvard Medical School, Pathology, Assistant Professor |
| 2016 - | Memorial Sloan Kettering Cancer, Director of Pathology Digital Imaging, Department of Pathology |
| 2017 - | Visiting Associate Professor, IIR, Tokyo Institute of Technology |
| 1994 | Distinguished Service Medal (Nikon) |
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| 2000 | Advanced Pathology Informatics, Imaging and the Internet (APIII) Honourable Mention – Electronic poster |
| 2011 | Japan Telepathology, Virtual Microscopy Association Distinguished Service Medal in Digital Pathology |
| 2006 | John R Gilbertson, Jonhan Ho, Leslie Anthony, Drazen M Jukic, Yukako Yagi and Anil V Parwani, “Primary histologic diagnosis using automated whole slide imaging: a validation study”, BMC Clinical Pathology 2006, 6:4. |
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| 2009 | Ronald S.Weinstein, Anna R.Graham, C.Richter, Gail P.Barker, Elizabeth A.Krupinski, Ana Maria Lopez, Kristine A.Erpsa, Achyut K.Bhattacharyya, Yukako Yagi, John R.Gilbertson, “Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future”, Human Pathology, Vol. 40, No. 8, pp. 1057-1069 (2009). |
| 2012 | Yagi Y, Pantanowitz L. Comment on “Quality evaluation of microscopy and scanned histological images for diagnostic purposes”: Are scanners better than microscopes? J Pathol Inform. 2012;3:14. Epub 2012 Apr 18. PMID: 22616026 |
| 2016 | Yagi Y, Riedlinger G, Xu X, Nakamura A, Levy B, Iafrate AJ, Mino-Kenudson M, Klepeis VE. “Development of a database system and image viewer to assist in the correlation of histopathologic features and digital image analysis with clinical and molecular genetic information “, Pathol Int. 2016 Feb;66(2):63-74. doi: 10.1111/pin.12382. Epub 2016 Jan 18. PMID: 26778830 |
| 2018 | 2018 Yagi Lab Publications, Speaking Events and Accepted Abstracts Publications The importance of eSlide macro images for primary diagnosis with whole slide imaging Towards machine learned quality control: A benchmark for sharpness quantification in digital pathology. Evaluation of an Automated Tissue Sectioning Machine for Digital Pathology Submitted Publications Validation of detection of mitotic cells via microscopy and using multiple whole-slide scanners Practical image quality evaluation for whole slide imaging scanner Development of Standard Operating Procedure (SOP) of Micro-computed tomography (micro-CT) in Pathology Invited Lectures Yagi, Yukako, PhD. (2018, March). 3D Imaging in Pathology, Hepato-Pancreato-Biliary (HPB) Surgery and Center for Pancreatic Cancer Weekly Research Conference, MSKCC, New York, NY. Yagi, Yukako, PhD. (2018, March). Digital Pathology and Computational Pathology Initiative at Memorial Sloan Kettering (MSK) Cancer Center, International Seminar Series on Biomedical Engineering, Chiba University Hospital, Chiba Japan. Yagi, Yukako, PhD. (2018, April). The Roles of Confocal Whole Slide Imaging in Cancer Research, The Annual Meeting of The American Association of Cancer Research, Chicago, IL. Yagi, Yukako, PhD. (2018, April). Whole Slide Imaging to Whole Block Imaging: Applications in Clinical and Research, Pathology Grand Rounds, Cedars-Sinai Hospital, Los Angeles, CA. Yagi, Yukako, PhD. (2018, May). The Warren Alpert Center’s Digital Imaging Laboratory, The First Annual Warren Alpert Center for Digital and Computational Pathology Spring Uraoka, Naohiro, MD, PhD. (2018, May). Toward automated Molecular Analysis, The First Annual Warren Alpert Center for Digital and Computational Pathology Spring Symposium, Tabata, Kazuhiro, MD, PhD. (2018, May). Validation Study of Mitotic Detection using a Microscope and Multiple Whole Slide Scanners, The First Annual Warren Alpert Center for Digital and Computational Pathology Spring Symposium, New York, NY. Teplov, Alexei. (2018, May). Micro-CT in Pathology, The First Annual Warren Alpert Center for Digital and Computational Pathology Spring Symposium, New York, NY. Yagi, Yukako, PhD. (2018, June). Digital Pathology and Cytology in US, The 59th Annual Spring Meeting of the Japanese Society of Clinical Cytology, Sapporo, Japan. Yagi, Yukako, PhD. (2018, June). Challenges & Strategies for Day-to-Day Use of Digital Pathology, Panel discussion. Digital Pathology & AI Congress: USA, New York, NY. Yagi, Yukako, PhD. (2018, June). Standardization, Digital Pathology & AI Congress: USA, Round Table, New York, NY. Yagi, Yukako, PhD. (2018, August). Digital and Computational Pathology for New Frontier in Pathology, 17th Annual Meeting of Japanese Society of Digital Pathology, Kure, Japan. Yagi, Yukako, PhD. (2018, August). How to Progress Digital Pathology in Japan, International Symposium, 17th Annual Meeting of Japanese Society of Digital Pathology, Kure, Japan. Yagi, Yukako, PhD. (2018, September). Digital Pathology Clinical Application (Non-Primary Diagnosis) using Super Ultra-Fast WSI Scanner, Sponsor’s symposium, European Congress of Pathology 2018, Bilbao, Spain. Yagi, Yukako, PhD. (2018, September). Whole Block Imaging, IT Workshop, European Congress of Pathology 2018, Bilbao, Spain. Yagi, Yukako, PhD. (2018, September). Toward the Automated Scoring of Fluorescence in situ Hybridization Using a Confocal Whole Slide Image Scanner, the Working Group Molecular Pathology, European Congress of Pathology 2018, Bilbao, Spain. Yagi, Yukako, PhD. (2018, September). Understanding Lung Cancer Pathobiology by 3D Imaging of Human Tumors, Thoracic Surgery Research Conference, MSKCC. New York, NY. Selected Abstracts Yagi, Yukako, PhD. (2018). Whole Block Imaging in Bone Tumor, The United States and Canadian Academy of Pathology 2018, Vancouver, Canada. Yagi, Yukako, PhD. (2018). Three-Dimensional Morphology of the Prostate by MicroCT, The United States and Canadian Academy of Pathology 2018, Vancouver, Canada. Yagi, Yukako, PhD. (2018). The Roles of Micro-Computed Tomography (CT) in Breast Pathology, The United States and Canadian Academy of Pathology 2018, Vancouver, Canada. Yagi, Yukako, PhD. (2018). Toward the Automated Scoring of Fluorescence in situ Hybridization Using a Confocal Whole Slide Image Scanner, European Congress of Pathology 2018, Bilbao, Spain. Yagi, Yukako, PhD. (2018). Three-Dimensional Visualization of the Dynamic Co-Option of Spread through Air Spaces (STAS) in Lung Adenocarcinoma, International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer, Toronto, Canada. Posters Tabata, Kazuhiro, MD, PhD. (2018, March). The Roles of Micro-Computed Tomography (micro-CT) in Breast Pathology, The United States and Canadian Academy of Pathology 2018, Vancouver, Canada. Yagi, Yukako, PhD. (2018, March). Whole Block Imaging in Bone Tumor, The United States and Canadian Academy of Pathology 2018, Vancouver, Canada. Yagi, Yukako, PhD. (2018, March). Three-Dimensional Morphology of the Prostate by Micro-CT, The United States and Canadian Academy of Pathology 2018, Vancouver, Canada. Fu, Xiujin, MD. (2018, March). Evaluation of an Automated Tissue Sectioning Machine for Digital Pathology, The United States and Canadian Academy of Pathology 2018, Vancouver, Fu, Xiujun, MD. (2018, March). Application of a Confocal WSI Scanner for FISH Slide Imaging, 3D Reconstruction, and Semi-Automated Diagnosis, The United States and Canadian Academy of Pathology 2018, Vancouver, Canada. Tabata, Kazuhiro, MD, PhD. (2018, May). The Roles of Micro-Computed Tomography (micro- CT) in Breast Pathology, The First Annual Warren Alpert Center for Digital and Computational Pathology Spring Symposium, New York, NY. Yagi, Yukako, PhD. (2018, May). Whole Block Imaging in Bone Tumor, The First Annual Warren Alpert Center for Digital and Computational Pathology Spring Symposium, New York, NY. Yagi, Yukako, PhD. (2018, May). Three-Dimensional Morphology of the Prostate by Micro-CT, The First Annual Warren Alpert Center for Digital and Computational Pathology Spring Fu, Xiujin, MD. (2018, May). Evaluation of an Automated Tissue Sectioning Machine forDigital Pathology, The First Annual Warren Alpert Center for Digital and ComputationalPathology Spring Symposium, New York, NY. Fu, Xiujun, MD. (2018, May). Application of a Confocal WSI Scanner for FISH Slide Imaging, 3D Reconstruction, and Semi-Automated Diagnosis, The First Annual Warren Alpert Center for Digital and Computational Pathology Spring Symposium, New York, NY. |