Debabrata Maiti博士が特任教授として科学技術創成研究院に着任しました。
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Debabrata Maiti特任教授に、小山二三夫科学技術創成研究院長より辞令交付しました。（左から小山研究院長、Debabrata Maiti特任教授、穐田宗隆教授）
＜Field of Specialization＞
Organic synthesis, Bio-inspired catalysis, Photoredox catalysis, Lignin valorization, Heterocyclic chemistry
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Collaborate research plan＞
Mastering of meticulous template designing have led to molecular complexity via selective functionalizations at meta- and para- postions of aromatic systems and various distal positions of aliphatic systems encountering thermodynamically disfavored large membered metallacycle. Although Prof. D. Maiti’s group has established themselves in this platform of achieving the unattained functionalizations at remote positions of different organic small molecules, what this collaborative venture look forward is to take this avenue to a stage where they can be routinely applied to access pharmaceuticals and agrochemicals via step and atom economic pathway. One of the prime characteristics of the pharmaceuticals and agrochemicals application is the environmentally friendly reaction condition. What we intend at present is to venture out at the visible-light-induced photoredox catalysis reactions at the distal carbon-hydrogen (C–H) bonds that could provide much needed new routes for the construction of the valuable molecules. Current methods are limited by the stoichiometric installation of template or directing groups (DGs), which are undesirable for large scale synthesis as it would require additional steps for installation and removal of DGs. Moreover, the strategy may not be feasible in the absence of an appropriate functional group on which to attach it. In the perspective of visible-light-induced photoredox catalysis distal C-H functionalization, we envisioned the meticulous designing of strategies would bind a substrate in a reversible manner and also have binding pocket that would enable the DG to selectively functionalize a suitably oriented distal C-H bond to be functionalized leading to the generation of the desired molecule. Host group has contributed immensely in the field of visible-light-induced photoredox catalysis through seminal discoveries of different concepts. Together, this collaborative venture will uncover strategies to access pharmaceuticals and agrochemicals via step and atom economic pathway.
＜Results of the research at WRHI, etc. and its effect for constructing the research hub＞
The research exposure while working at the excellent environment at WRHI will acquaint with the different approaches employed by the host’s group as well as guest’s groups. This collaborative venture will help towards designing and synthesizing target-specific molecules. While working at the WRHI, we expect to publish beyond-the-state-of-the-art science together. The experience of working will also aid in improving contacts and building a robust network in the Japanese scientific fraternity, which will directly influence groups in terms of advancement of ideas and research problems. The direct interactions with peers and senior scientists in the field will actuate engagement in terms of collaborative research projects and exchange of ideas which would be mutually beneficial.
＜Expected effect＞
For a successful execution of the envisaged proposal, our collaborative association would be immensely useful. Host Professor’s expertise merging with Prof. D. Maiti’s domain of template designing will help solving the long standing problems associated with the distal C-H functionalizations and thereby we can channelize them in overcoming the existing difficulties. Moreover, infrastructure in Prof. Akita’s lab at Laboratory for Chemistry and Life Science, Tokyo Institute of Technology would be apt in implementing the joint endeavor. We sincerely hope that getting adequate funding will give us the flexibility to continue outstanding research findings and advancing the current state of the scientific discovery at the host institution.
＜共同研究者＞
東京工業大学科学技術創成研究院化学生命科学研究所 穐田宗隆教授