細胞生物学研究
Jinhua Dong
特任教授
遺伝子工学 蛋白質工学 抗体工学 免疫測定
研究プロジェクト
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提示技術による新型抗体の開発及び応用
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Open Sandwich免疫測定法及びQuenchbody免疫蛍光プローブの研究
| 2007-2009 |
東京大学大学院工学系研究科リサーチフェロー |
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| 2009-2011 |
日本学術振興会外国人特別研究員(東京大学) |
| 2011-2013 |
静岡大学創造科学技術大学院研究員、特任助教 |
| 2013-2016 |
東京工業大学 資源化学研究所 助教 |
| 2016-2017 |
臨沂大学化学化工学院 教授 |
| 2017- |
東京工業大学科学技術創成研究院 特任教授 |
| 2017 |
Excellent Paper Award of The Society for Biotechnology, Japan |
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| 2015 |
フジサンケイビジネスアイ第29回独創性を拓く先端技術大賞特別賞 |
| 2020 |
Dong, J., Miyake, C., Yasuda, T., Oyama, H., Morita, I., Tsukahara, T., Takahashi, M., Jeong, H.J., Kitaguchi, T., Kobayashi, N., and Ueda, H., PM Q-probe: a fluorescent binding protein that converts many antibodies to a fluorescent biosensor, Biosens. Bioelectron, 165,112425, 2020 Dong, J., Oka, Y., Jeong, H.J., Ohmuro-Matsuyama, Y., and Ueda, H., Detection and destruction of HER2-positive cancer cells by Ultra Quenchbody-siRNA complex, Biotechnol. Bioeng., 117, 1259-1269, 2020 |
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| 2019 |
Cong, Y., Dong, H., Wei, X., Zhang, L., Bai, J., Wu, J., Huang, X.J., Gao, Z., Ueda, H. and Dong, J., A novel murine antibody and an Open sandwich immunoassay for the detection of clenbuterol, Ecotoxicol. Environ. Saf., 182,109473, 2019 Gong, Z., Liu, X., Dong, J., Zhang, W., Jiang, Y., Zhang, J., Feng, W., Chen, K., Bai, J., Transition from vesicles to nanofibres in the enzymatic self-assemblies of an amphiphilic peptide as an antitumour drug carrier, Nanoscale, 11(33):15479-15486, 2019 |
| 2018 |
Dong, J., Fujita, R., Zako, T., Ueda, H., Construction of Quenchbodies to detect and image Amyloid β oligomers, Anal. Biochem., 550,61-67, 2018 Zhao, S., Dong, J., Jeong, H.J., Okumura, K., Ueda, H., Rapid detection of the neonicotinoid insecticide imidacloprid using a quenchbody assay, Anal. Bioanal. Chem., 410(17),4219-4226, 2018 Su, J., Dong, J., Kitaguchi, T., Ohmuro-Matsuyama, Y., Ueda, H., Noncompetitive homogeneous immunodetection of small molecules based on β-glucuronidase complementation, Analyst, 143, 2096-2101, 2018 |
| 2017 |
Dong, J., Shichiri, M., Chung, C.I., Shibata, T., Uchida, K., Hagihara, Y., Yoshida, Y., Ueda, H., An Open Sandwich immunoassay for detection of 13(R,S)-Hydroxy-9(E),11(E)-octadecadienoic acid, Analyst, 142(5), 787-793, 2017 Dong, J., Ueda, H., ELISA-type assays of trace biomarkers using microfluidic methods, WIREs Nanomed. Nanobiotechnol., e1457, 2017 Wongso, D., Dong, J., Ueda, H., Kitaguchi, T., Flashbody: a next generation Fluobody with fluorescence intensity enhanced by antigen binding, Anal. Chem., 89(12),6719-6725, 2017 Jeong, H.J., Kawamura, T., Iida, M., Kawahigashi, Y., Takigawa, M., Ohmuro-Matsuyama, M., Chung, C.I., Dong, J., Kondoh, M., Ueda, H., Development of a Quenchbody for the detection and imaging of the cancer-related tight-junction-associated membrane protein claudin, Anal Chem., 89(20),10783-10789, 2017 |
| 2016 |
Dong, J., Jeong, H.J., Ueda, H., Preparation of Quenchbodies by protein transamination reaction, J. Biosci. Bioeng., 122(1), 125-130, 2016 |
| 2015 |
Dong, J., Kojima, T., Ohashi H., Ueda, H., Optimal fusion of antibody binding domains resulted in higher affinity and wider specificity, J. Biosci. Bioeng., 120(5),504-9, 2015 Chung, C.I., Makino, R., Dong, J., Ueda, H., Open flower fluoroimmunoassay: a general method to make fluorescent protein-based immunosensor probes, Anal. Chem., 87(6), 3513-9, 2015 |
| 2014 |
Dong, J., Otsuki, T., Kato, T., Park, E.Y., Tracking Neospora caninum parasites using chimera monoclonal antibodies against its surface antigen-related sequences (rNcSRS2), J. Biosci. Bioeng., 117(3), 351-357, 2014 |
| 2013 |
Zhou, H.*, Dong, J.*, Deo, V.K., Park, E.Y., Lee, J. Detection of anti-Neospora antibodies in bovine serum by using spiky Au-CdTe nanocomplexes, Sens. actuators. B Chem., 178,192-199 (2013) *equal contributions Dong, J., Sakurai, A., Nomura, N., Park, E.Y., Shibasaki, F., Ueda, H., Isolation of recombinant phage antibodies targeting the hemagglutinin cleavage site of highly pathogenic avian influenza virus, PloS One, 8(4), e61158, 2013 |
| 2012 |
Dong, J., Otsuki, T., Kato, T., Park, E.Y., Development of a diagnostic method for neosporosis in cattle using recombinant Neospora caninum proteins, BMC Biotechnol., 12,19, 2012 |
| 2011 |
Islam, K., Ihara, M., Dong, J., Kasagi, N., Mori, T., Ueda, H., Direct construction of open-sandwich enzyme immunoassay for one-step noncompetitive detection of thyroid hormone T4, Anal. Chem., 83(3),1008-1014, 2011 |
| 2009 |
Dong, J., Ihara, M., Ueda, H., Antibody Fab display system that can perform open-sandwich ELISA, Anal. Biochem., 386(1),36-44, 2009 |
| 2007 |
Dong, J., Tamaru, Araki, T., Molecular cloning, expression, and characterization of a β-agarase gene, agaD, from a marine bacterium, Vibrio sp. strain PO-303, Biosci. Biotechnol. Biochem., 71(1),38-46, 2007 Dong, J., Tamaru, Y., Araki, T., A unique β-agarase, AgaA, from a marine bacterium, Vibrio sp. strain PO-303, Appl. Microbiol. Biot., 74(6),1248-1255, 2007 |
| 2006 |
Dong, J., Hashikawa, S., Konishi, T., Tamaru, Y., Araki, T., Cloning of the novel gene encoding β-Agarase C from a marine bacterium, Vibrio sp. strain PO-303, and characterization of the gene product, Appl. Environ. Microbiol., 72(9),6399-6410, 2006 |