細胞生物学研究
Hiroshi Iwasaki 岩﨑 博史
教授
染色体動態 相同組換え 接合型変換 分子生物学 分子遺伝学
研究プロジェクト
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岩﨑研究室は、相同組換えや接合型変換の分子機構を研究しています。
| 1991–2001 |
大阪大学微生物病研究所 助手 |
|---|---|
| 2001–2005 |
横浜市立大学 助教授 |
| 2005–2007 |
横浜市立大学 准教授 |
| 2007–2009 |
横浜市立大学 教授 |
| 2009 – |
東京工業大学 教授 |
| 1992 |
井上研究奨励賞 |
|---|---|
| 2001 |
日本遺伝学会奨励賞 |
| 2013 |
文部科学大臣表彰 科学技術賞（研究部門） |
| 2016 |
日本遺伝学会 木原賞 |
| 2018 |
New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe. Takahisa Maki, Naoto Ogura, James E Haber, Hiroshi Iwasaki, Genevieve Thon. PLoS Genet. (2018) 14(5):e1007424. Establishment of DNA-DNA interactions by the cohesin ring. Yasuto Murayama, Catarina P. Samora, Yumiko Kurokawa, Hiroshi Iwasaki, Frank Uhlmann. Cell (2018) 172: 465-477. |
|---|---|
| 2017 |
Holliday-junction resolvases that mediate chloroplast nucleoid segregation. Kobayashi Y, Misumi O, Odahara M, Ishibashi K, Hirono M, Hidaka K, Endo M, Sugiyama H, Iwasaki H, Kuroiwa T, Shikanai T, Nishimura Y. Science (2017) 356(6338), 631-634. |
| 2014 |
Multiple regulation of rad51-mediated homologous recombination by fission yeast fbh1. Tsutsui Y, Kurokawa Y, Ito K, Siddique MS, Kawano Y, Yamao F and Iwasaki H. PLoS Genet . (2014) 28. e1004542. doi: 10.1371/journal.pgen.1004542. |
| 2013 |
Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition. Murayama Y, Kurokawa Y, Tsutsui Y and Iwasaki H. Genes Dev . (2013) 27, 2299-2304. |
| 2012 |
Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex. Kuwabara N, Murayama Y, Hashimoto H, Kokabu Y, Ikeguchi M, Sato M, Mayanagi K, Tsutsui Y, Iwasaki H and Shimizu T. Structure (2012) 20, 440-449. |
| 2011 |
The fission yeast meiosis-specific Dmc1 recombinase mediates formation and branch migration of Holliday junctions by preferentially promoting strand-exchange in a direction opposite to that of Rad51. Murayama Y, Tsutsui Y and Iwasaki H. Genes Dev . (2011) 25, 516-527. |
| 2009 |
RAD6-RAD18-RAD5 pathway-dependent tolerance to chronic low-dose UV light. Hishida T, Kubota Y, Carr AM, and Iwasaki H. Nature (2009) 457, 612-615. |
| 2008 |
Reconstitution of DNA strand exchange mediated by Rhp51 recombinase and two mediators. Kurokawa Y, Murayama Y, Haruta-Takahashi N, Urabe I and Iwasaki H. PLoS Biol (2008) 6: e88. Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases. Murayama Y, Kurokawa Y, Mayanagi K and Iwasaki H. Nature (2008) 451, 1018-1021. |
| 2007 |
Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes. Akamatsu Y, Tsutsui Y, Morishita T, Siddique, MDP, Kurokawa, Y. Ikeguchi M, Yamao F, Arcangioli B and Iwasaki H. EMBO J . (2007) 26, 1352-1362. |
| 2006 |
The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro. Haruta N, Kurokawa Y, Murayama Y, Akamatsu Y, Unzai S, Tsutsui Y and Iwasaki H. Nature Struct. Mol. Biol . (2006) 13, 823-730. |
| 2003 |
Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast. Akamatsu Y, Dziadkowiec D, Ikeguchi M, Shinagawa H and Iwasaki H. Proc. Natl. Acad. Sci . USA . (2003) 100, 15770-15775. |