細胞生物学研究
Virginijus Siksnys
特任教授
Biochemistry CRISPR-Cas9
トピックス
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The Kavli Prize in Nanoscience 2018 was awarded to Dr. Virginijus Siksnys for the invention of CRISPR-Cas9, a precise nanotool for editing DNA, causing a revolution in biology, agriculture, and medicine.
| 2019- |
Specially Appointed Professor, School of Life Science and Technology, Tokyo Institute of Technology |
|---|---|
| 2019- |
Distinguished Professor/Chief Staff Scientist, Vilnius University |
| 2010-2018 |
Chief Staff Scientist/ Head of Department, Institute of Biotechnology, Vilnius University |
| 2002-2010 |
Professor, Vilnius University (part time) |
| 2002-2010 |
Chief Staff Scientist/ Head of Department, Institute of Biotechnology, Vilnius University |
| 1996-2002 |
Senior Staff Scientist, Head of Laboratory, Institute of Biotechnology, Vilnius University |
| 1994 |
Visiting Scientist, Max-Planck-Institute of Biochemistry, Martinsried, Germany |
| 1987-1996 |
Senior Research Fellow/Group Leader Institute of Applied Enzymology, Vilnius University |
| 1985-1986 |
Senior Research Fellow, Institute of Applied Enzymology, Vilnius University |
| 1981-1985 |
Junior Research Fellow, Institute of Applied Enzymology, Vilnius University |
| 2018 |
The Kavli Prize |
|---|---|
| 2018 |
Honorary doctorate of University of Bristol |
| 2018 |
Lithuania National Science Award |
| 2017 |
NovoNordisk Novozyme Prize |
| 2016 |
Grand Duke Gediminas Order of the State of Lithuania |
| 2016 |
Warren Alpert Prize |
| 2015 |
St. Christophorus award of Vilnius city |
| 2012 |
Lithuania’s Scientist of the year |
| 2001-2005 |
Howard Hughes Medical Institute International scholarship |
| 2001 |
Lithuania National Science Award |
| 2017 |
Kazlauskiene M, Kostiuk G, Venclovas Č, Tamulaitis G, Siksnys V. A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems. Science. 2017, 357, 605-60. |
|---|---|
| 2016 |
Kazlauskiene M, Tamulaitis G, Kostiuk G, Venclovas Č, Siksnys V. Spatiotemporal Control of Type III-A CRISPR-Cas Immunity: Coupling DNA Degradation with the Target RNA Recognition. Mol Cell. 2016, 62, 295-306. |
| 2015 |
Glemzaite, M. Balciunaite, E. Karvelis, T. Gasiunas, G. Alzbutas, G. Jurcyte, A. Anderson, E.M. Maksimova, M. Smith, A.J. Lubys, A. Zaliauskiene, L. Siksnys, V. Targeted gene editing by transfection of in vitro reconstituted Streptococcus thermophilus Cas9 nuclease complex, RNA Biology. 2015,12, 1-4. |
| 2015 |
Karvelis T, Gasiunas G, Young J, Bigelyte G, Silanskas A, Cigan M, Siksnys V. Rapid |
| 2014 |
Tamulaitis G. Kazlauskiene, M. Manakova, M. Venclovas, C. Nwokeoji, A.O. Dickman, M.J. Horvath, P. Siksnys V. Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus. Molecular Cell 2014, 56, 506-17. |
| 2013 |
Sinkunas T, Gasiunas G, Waghmare SP, Dickman MJ, Barrangou R, Horvath P, Siksnys V. In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus. EMBO J. 2013; 2, 385-94. |
| 2013 |
Karvelis T, Gasiunas G, Miksys A, Barrangou R, Horvath P, Siksnys V. crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus. RNA Biol. 2013, 10, 841-51. |
| 2012 |
Gasiunas G, Barrangou R, Horvath P, Siksnys V. Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc Natl Acad Sci U S A. 2012, 109, E2579-86. |
| 2011 |
Sinkunas T, Gasiunas G, Fremaux C, Barrangou R, Horvath P, Siksnys V. Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system. EMBO J. 2011, 30:1335-42. |
| 2011 |
Sapranauskas R, Gasiunas G, Fremaux C, Barrangou R, Horvath P, Siksnys V. The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli. Nucleic Acids Res. 2011, 39, 9275-82. |